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Is Olfactory Epithelium Biopsy Useful for Confirming Alzheimer's Disease?

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Date
2019-03
Author
Godoy, Maria Dantas Costa Lima
Author
Fornazieri, Marco Aurélio
Author
Doty, Richard L.
Author
Pinna, Fábio de Rezende
Author
Farfel, José Marcelo
Author
Santos, Glaucia Bento dos
Author
Molina, Mariana
Author
Ferretti-Rebustini, Renata E. L.
Author
Leite, Renata E. P.
Author
Suemoto, Claudia K.
Author
Grinberg, Lea T.
Author
Pasqualucci, Carlos A. G.
Author
Voegels, Richard Louis
Author
Nitrini, Ricardo
Author
Jacob Filho, Wilson
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Artigo
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Abstract
OBJECTIVES: The clinical symptoms of Alzheimer’s disease (AD) are preceded by a long asymptomatic period associated with “silent” deposition of aberrant paired helical filament (PHF)-tau and amyloid-beta proteins in brain tissue. Similar depositions have been reported within the olfactory epithelium (OE), a tissue that can be biopsied in vivo. The degree to which such biopsies are useful in identifying AD is controversial. This postmortem study had 3 main goals: first, to quantify the relative densities of AD-related proteins in 3 regions of the olfactory neuroepithelium, namely, the nasal septum, middle turbinate, and superior turbinate; second, to establish whether such densities are correlated among these epithelial regions as well as with semi-quantitative ratings of general brain cortex pathology; and third, to evaluate correlations between the protein densities and measures of antemortem cognitive function.
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Ann Otol Rhinol Laryngol. 2019 Mar;128(3):184-192. doi: 10.1177/0003489418814865.
xmlui.dri2xhtml.METS-1.0.item-source-uri
https://doi.org/10.1177/0003489418814865
Subject
Alzheimer’s Disease
 
Aging
 
Immunohistochemistry
 
Olfactory Mucosa
 
Olfaction
 
Olfaction Disorders
 
URI
http://digital.bibliotecaorl.org.br/handle/forl/437
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  • Artigo [8]

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Contact Us | Send Feedback

Divisão de Biblioteca e Documentação do Departamento
de Otorrinolaringologia da Faculdade de Medicina USP

Rua Artur de Azevedo, 46 CEP: 05404-000 São Paulo/SP - Brasil

Tel: (11) 3062-4097 Email: biblioteca@forl.org.br

Medicina USPFORL
Desenvolvido por Logo DGL Sistemas