Artigohttp://digital.bibliotecaorl.org.br/handle/forl/342024-03-29T15:21:56Z2024-03-29T15:21:56ZThe digital scent device as a new concept for olfactory assessment.Nakanishi, MarcioFornazieri, Marco AurélioLança Gomes, PedroDias, Luis Augusto de MirandaFreire, Gustavo Subtil MagalhãesVinha, Luís Gustavo do AmaralBarbosa de Sa, Leonardo ConradoVoegels, Richard LouisGalvão, ClaudiaLima, Wilma Terezinha Anselmohttp://digital.bibliotecaorl.org.br/handle/forl/4782022-10-27T12:29:20Z2022-10-01T00:00:00ZThe digital scent device as a new concept for olfactory assessment.
Nakanishi, Marcio; Fornazieri, Marco Aurélio; Lança Gomes, Pedro; Dias, Luis Augusto de Miranda; Freire, Gustavo Subtil Magalhães; Vinha, Luís Gustavo do Amaral; Barbosa de Sa, Leonardo Conrado; Voegels, Richard Louis; Galvão, Claudia; Lima, Wilma Terezinha Anselmo
Background: There are major challenges in olfactory measurements in clinical practice; therefore, a handheld digital scent device (DSD; Noar MultiScent 20) was developed as a tablet with an integrated storage system for odors. The DSD is a self-administered, handheld device that controls the duration of odor release to the nasal cavity through a touchscreen digital interface with automatic database generation. In this study we aimed to determine the feasibility of this DSD as an olfactory assessment test.
Methods: We recruited 180 participants (age [mean ± standard deviation], 34.58 ± 9.71 years; 114 women and 66 men) to participate in smell tests using both the DSD and the 40-item Smell Identification Test (SIT-40), which contained the same type and order of odors and the same multiple-choice answers. The scores were compared and evaluated for correlation between the tests, and test-retest reliability was calculated.
Results: The DSD test scores were higher than the SIT-40 scores (median [interquartile range], 32 [5.0] vs 31 [7.0]; p = 0.005). The completion time was less for the DSD test than for the SIT-40 (12.5 [5.0] vs 16 [6.0] minutes; p < 0.001). The tests were strongly correlated (Spearman rho = 0.74; p < 0.001) and exhibited a high level of agreement (Bland-Altman regression coefficient = 0.672; p = 0.003). The DSD test-retest reliability coefficient was 0.820.
Conclusion: The DSD is feasible as an olfactory assessment test. The digitalization of olfactory assessment combined with data science may enable new research perspectives in the field of olfaction.
2022-10-01T00:00:00ZThe effects of adenoidectomy on the smell perception of children.Fornazieri, Marco AurélioAraújo, Rafael GoulartLima, João Vitor FernandesFavareto, Felipe BaysPinna, Fábio de RezendeVoegels, Richard LouisDoty, Richard L.http://digital.bibliotecaorl.org.br/handle/forl/4412020-09-14T14:27:25Z2019-01-01T00:00:00ZThe effects of adenoidectomy on the smell perception of children.
Fornazieri, Marco Aurélio; Araújo, Rafael Goulart; Lima, João Vitor Fernandes; Favareto, Felipe Bays; Pinna, Fábio de Rezende; Voegels, Richard Louis; Doty, Richard L.
BACKGROUND: In this study, we employed a novel children's olfactory test in order to more accurately assess the relationship between nasopharyngeal obstruction and odor identification ability. We quantified the impact of adenoidectomy on olfactory function, established whether the influences of the operation were related to the preoperative amount of nasopharyngeal obstruction, and determined whether sex influenced the olfactory measures. METHODS: Fifty‐three boys and 23 girls were administered a standardized children's olfactory test, the Pediatric Smell Wheel™, before and 45 days after adenoidectomy. They ranged in age from 5 to 12 years and exhibited varying degrees of adenotonsillar hypertrophy and histories of recurrent adenotonsillitis. Radiographs of the nasopharynx were used to grade the degree of nasopharyngeal obstruction. RESULTS: Significant postoperative improvement in smell function occurred more frequently in children with >50% preoperative obstruction of the nasopharynx. In this group, average function improved 50.8% after surgery (95% confidence interval [CI], 39.1% to 64%). Improvement on 9 of the 11 odors was present, with significant differences occurring for the odors of bubble gum, baby powder, mint, and cinnamon. No sex differences were evident. CONCLUSION: Olfactory dysfunction occurs primarily in children whose nasopharyngeal obstruction is >50%. Removal of the hypertrophied adenoids returned smell function back to normal in these cases. This study suggests that smell loss may be of value in decisions regarding whether or not to perform adenoidectomy in children with nasopharyngeal obstruction.
2019-01-01T00:00:00ZGustatory disturbances occur in patients with head and neck cancer who undergo radiotherapy not directed to the oral cavitySilva, José Lucas Barbosa daDoty, Richard L.Massamitsu, João VictorMiyazaki, KatayamaBorges, RicardoPinna, Fábio de RezendeVoegels, Richard LouisFornazieri, Marco Auréliohttp://digital.bibliotecaorl.org.br/handle/forl/4182020-09-14T14:06:09Z2019-08-01T00:00:00ZGustatory disturbances occur in patients with head and neck cancer who undergo radiotherapy not directed to the oral cavity
Silva, José Lucas Barbosa da; Doty, Richard L.; Massamitsu, João Victor; Miyazaki, Katayama; Borges, Ricardo; Pinna, Fábio de Rezende; Voegels, Richard Louis; Fornazieri, Marco Aurélio
INTRODUCTION: Even the most modern radiation techniques still result in some degree of toxicity to adjacent normal tissues. Consequently, the radiotherapy treatment in head and neck neoplasms potentially leads to gustatory dysfunction even in cases when the treatment area is outside or adjacent to the oral cavity. In this study we quantitatively and qualitatively assessed gustatory function in patients with head and neck cancers who underwent radiotherapy inside and outside of the oral cavity. METHODS: Fifty-six patients with head and neck cancer responded to a specific questionnaire and had their gustatory function tested before, immediately after, and at 3 and 6 months following radiotherapy treatment. The irradiation field did not include the oral cavity in 29 patients and included it in 27 patients. RESULTS: All patients suffered a severe loss of taste immediately after radiotherapy. The identification of sweet and bitter tastes decreased in both groups, but the sour decrement was exclusive to those who had the oral cavity irradiated. Fourteen percent of patients complained of qualitative changes of taste, namely taste distortions. No impact of xerostomia on the taste measures was apparent. CONCLUSION: We found that patients with head and neck neoplasms submitted to radiotherapy have disturbed taste even when irradiation does not include the oral cavity. This deficit is worse immediately after the end of radiotherapy. Our findings do not support the hypothesis that decreased salivary flow is the major cause for radiation-induced changes in taste function.
2019-08-01T00:00:00ZIs Olfactory Epithelium Biopsy Useful for Confirming Alzheimer's Disease?Godoy, Maria Dantas Costa LimaFornazieri, Marco AurélioDoty, Richard L.Pinna, Fábio de RezendeFarfel, José MarceloSantos, Glaucia Bento dosMolina, MarianaFerretti-Rebustini, Renata E. L.Leite, Renata E. P.Suemoto, Claudia K.Grinberg, Lea T.Pasqualucci, Carlos A. G.Voegels, Richard LouisNitrini, RicardoJacob Filho, Wilsonhttp://digital.bibliotecaorl.org.br/handle/forl/4372020-09-14T14:23:09Z2019-03-01T00:00:00ZIs Olfactory Epithelium Biopsy Useful for Confirming Alzheimer's Disease?
Godoy, Maria Dantas Costa Lima; Fornazieri, Marco Aurélio; Doty, Richard L.; Pinna, Fábio de Rezende; Farfel, José Marcelo; Santos, Glaucia Bento dos; Molina, Mariana; Ferretti-Rebustini, Renata E. L.; Leite, Renata E. P.; Suemoto, Claudia K.; Grinberg, Lea T.; Pasqualucci, Carlos A. G.; Voegels, Richard Louis; Nitrini, Ricardo; Jacob Filho, Wilson
OBJECTIVES: The clinical symptoms of Alzheimer’s disease (AD) are preceded by a long asymptomatic period associated with “silent” deposition of aberrant paired helical filament (PHF)-tau and amyloid-beta proteins in brain tissue. Similar depositions have been reported within the olfactory epithelium (OE), a tissue that can be biopsied in vivo. The degree to which such biopsies are useful in identifying AD is controversial. This postmortem study had 3 main goals: first, to quantify the relative densities of AD-related proteins in 3 regions of the olfactory neuroepithelium, namely, the nasal septum, middle turbinate, and superior turbinate; second, to establish whether such densities are correlated among these epithelial regions as well as with semi-quantitative ratings of general brain cortex pathology; and third, to evaluate correlations between the protein densities and measures of antemortem cognitive function.
2019-03-01T00:00:00Z