http://digital.bibliotecaorl.org.br/handle/forl/30 2026-04-08T03:15:31Z 2026-04-08T03:15:31Z Martinez-Marcos, Alino Trejo, José L. López-Mascaraque, Laura http://digital.bibliotecaorl.org.br/handle/forl/379 2020-08-31T03:59:09Z 2015-01-01T00:00:00Z

50th Anniversary of Adult Neurogenesis: Olfaction, hippocampus and beyond Martinez-Marcos, Alino; Trejo, José L.; López-Mascaraque, Laura In 1965, Altman and Das published their seminal article “Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats” (J. Comp. Neurol., 124: 319-335). During decades, this discovery was mostly neglected up to eighty’s when Fernando Nottebohm demonstrated adult neurogenesis in the avian brain related to bird song learning. In the following decade, two main niches of adulthood neurogenesis were characterized in the mammalian brain: the subventricular zone of the lateral ventricle from where neuroblasts migrate to the olfactory bulb and the subgranular layer of the dentate gyrus for turnover of hippocampal granule cells. Since then, a number of experimental data have tried to unravel the role of bulbar and hippocampal newly-born neurons. Among others, adult neurogenesis has been related to learning and memory, but its exact function in the pre-existing circuits is far from clear. It has been demonstrated that neurogenic rate can be regulated by external factors such as sensory stimuli, exercise, experience and stress. This rate can be altered during disease, particularly in neurodegenerative disorders, and its potential therapeutic capacity is being investigated even though this neurogenic capacity still needs to be further explored in human brain. This Research Topic is intended to review multidisciplinary advances during last half century from the adult neurogenesis discovery by worldwide leaders in the field.

2015-01-01T00:00:00Z Kowalski, Marek http://digital.bibliotecaorl.org.br/handle/forl/380 2020-09-02T01:37:37Z 2012-01-01T00:00:00Z

Allergic Rhinitis Kowalski, Marek Allergic rhinitis, while troublesome for a patient, may be also a challenge for the physician. That is why physicians must still learn more on the pathophysiology, clinical spectrum and novel diagnostic and therapeutic approaches to the disease. The chapters of this volume address a variety of important topics related to allergic rhinitis. They begin with a description of innovative translational approaches allowing for unification of animal and human models. Contributing authors provide up-to-date reviews of clinical aspects of allergic rhinitis in children, its association with bronchial asthma and other co-morbid conditions. They also discuss the impact of allergic rhinitis on sleep and sports. Together with articles on diagnostic approaches as well as novel treatments, the book offers a comprehensive and stimulating review of the topic. May this book find a wide readership among allergists and other physicians interested in allergic disease, and also among pediatricians, general practitioners and other specialists who increasingly have to deal with this seemingly benign, but sometimes extremely troublesome, disease.

2012-01-01T00:00:00Z Wang, Tang-Chuan http://digital.bibliotecaorl.org.br/handle/forl/248 2020-11-12T16:47:05Z 2019-01-01T00:00:00Z

Challenging Issues on Paranasal Sinuses Wang, Tang-Chuan Management of paranasal sinus disorders is not only a test of knowledge but it is also an art form. Great progress has been made on endoscopic sinus surgery in recent decades and this technique lets us look into the remote corners of sinuses. However, we still have a lot of challenging issues. The only way to solve these problems is to face them. Based on these concepts, this book incorporates new clinical and research developments as well as future perspectives in the ever-expanding field of rhinology. The book is a comprehensive reference for ENT residents and practicing otolaryngologists who wish to expand their expertise, develop a broader armamentarium of techniques, and successfully manage their patients with sinonasal disorders.

2019-01-01T00:00:00Z Farr, Sebastian Torres http://digital.bibliotecaorl.org.br/handle/forl/375 2020-08-31T02:17:02Z 2019-01-01T00:00:00Z

Contemporary Rhinoplasty Farr, Sebastian Torres Contemporary Rhinoplasty is a very direct book that presents the procedure from different aspects, giving perspective to the audience. It describes nasal aesthetics, diagnoses, surgical planning, and the learning curve of the procedure for the novel surgeon. It analyses local aspects and technical recommendations for the use of alar rim grafts and gives the reader enough light to understand the complex chapter on saddle nose deformity. It will intersect nasal surgery with morbid conditions such as sleep breathing disorders, clefts, and head and neck cancer. Whatever level of your expertise it will surely add something to your background and enhance your practice.

2019-01-01T00:00:00Z